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AFM was invented in 1985 by IBM scientists Gerd Binnig, Calvin Forrest Quate (19232019), and Christoph Gerber, who reported a development of a new type of microscope, which, being a combination of the principles of the scanning tunneling microscope [STM that was invented in 1981 by Gerd Binnig, Heinrich Rohrer (19332013), Christoph Gerber, and Edi Weibel ( Biomedical applications of AFM, which can operate in ambient air, high vacuum, and liquid environments, are centered at topographic imaging [e.g., it can resolve DNA double helix (Mou et al., 1995) or probe structure and dynamics of nucleosomes (Stumme-Diers et al., 2019), or visualize and provide topological information about amyloid fibrils (Lutter et al., 2020

Biol 10:122